ASP 2905 ( ASP2905;ASP-2905 )

产品货号. M15973 CAS No. 792184-90-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

拼团产品询价大包装询价加入购物车

产品名称

ASP 2905
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM.
产品描述

A novel potent, selective, orally bioavailable inhibitor of voltage-gated potassium channel KCNH3 with IC50 of 9.0 nM; displays minimally bound with low affinities to 55 transmembrane proteins; decreases the frequency of spontaneous inhibitory postsynaptic currents in cultured rat hippocampal neurons at 0.1-1 uM; reverses the disruption of spontaneous alternation behavior induced by MK-801 and scopolamine in mice, and ameliorates the cognitive deficits of aged rats.Alzheimer Disease Phase 1 Discontinued
同义词

ASP2905;ASP-2905
通路

Cell Cycle/DNA Damage
靶点

Potassium Channel
受体

Potassium Channel
研究领域

Neurological Disease
适应症

Alzheimer Disease

CAS Number

792184-90-8
分子量

388.41
分子式

C20H17FN8
纯度

>98% (HPLC)
溶解度

——
SMILES

FC(C=C1)=CC=C1NC2=NC(NC3=CC=CC=C3)=NC(NCC4=NC=CC=N4)=N2.Cl
化学全称

N-(4-fluorophenyl)-N'-phenyl-N''-(pyrimidin-2-ylmethyl)-1,3,5-triazine-2,4,6-triamine

1. Takahashi S, et al. Eur J Pharmacol. 2017 Sep 5;810:26-35.

计算器

产品手册

关联产品

PAP-1

PAP-1 is a selective, and orally active Kv1.3 blocker (EC50: 2 nM).
VU0071063

VU0071063 is a Kir6.2/SUR1 activator.
Phe-Met-Arg-Phe, ami...

Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons. This peptide appears to localize with neuropeptide Y in some regions of the brain.